Louisville Cardinals Lead Virginia Tech Hokies 1-0 in Head-to-Head Matchups (2025-26)

NCAAF1-0-0 ATS (100%)Updated November 1, 2025

The Louisville Cardinals are 1-0 against the Virginia Tech Hokies in 2025-26 in head-to-head matchups, going 1-0-0 ATS (100% cover rate) with +92.59% ROI. Games average 44 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cardinals vs Hokies Betting Record — 2025-26

Against the Spread

1-0-0

Win %

100%

ROI

+92.59%

Units

+0.9

Moneyline

1-0-0

Win %

100%

ROI

+27.78%

Units

+0.3

Over Rate

0-1-0

Win %

ROI

-100%

Units

-1.0

From the Other Side — Hokies vs Cardinals

Against the Spread

0-1-0

Win %

ROI

-100%

Units

-1.0

Moneyline

0-1-0

Win %

ROI

-100%

Units

-1.0

Over Rate

0-1-0

Win %

ROI

-100%

Units

-1.0

Venue Splits

Cardinals Home

Hokies Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Cardinals

PPG

allowed

Total

Avg

games

Hokies

PPG

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
11/012025-11-01	Cardinals @ Hokies	W 16-28	-10	✓	W	U

Frequently Asked Questions

What is the Louisville Cardinals vs Virginia Tech Hokies 2025-26 record?

The Louisville Cardinals are 1-0 against the Virginia Tech Hokies in 2025-26 in head-to-head matchups.

What is the Louisville Cardinals ATS record vs the Virginia Tech Hokies?

The Louisville Cardinals are 1-0-0 against the spread vs the Virginia Tech Hokies in 2025-26 on DraftKings, with +92.59% ROI.

Do Louisville Cardinals vs Virginia Tech Hokies games go over or under?

Louisville Cardinals vs Virginia Tech Hokies games average 44 total points in 2025-26. The Over has hit 0% of the time.

More Cardinals Matchups

See from Hokies perspective

Head-to-head betting record for Louisville Cardinals vs Virginia Tech Hokies in the 2025-26 season on LineTerminal. The Cardinals are 1-0 straight up against the Hokies and 1-0-0 against the spread (100% cover rate, +92.59% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.