Louisville Cardinals Lead Virginia Tech Hokies 2-0 in Head-to-Head Matchups

NCAAF2-0-0 ATS (100%)Updated November 1, 2025

The Louisville Cardinals are 2-0 against the Virginia Tech Hokies in head-to-head matchups, going 2-0-0 ATS (100% cover rate) with +91.75% ROI. Games average 40.5 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cardinals vs Hokies Betting Record

Against the Spread

2-0-0

Win %

100%

ROI

+91.75%

Units

+1.8

Moneyline

2-0-0

Win %

100%

ROI

+28.59%

Units

+0.6

Over Rate

0-2-0

Win %

ROI

-100%

Units

-2.0

From the Other Side — Hokies vs Cardinals

Against the Spread

0-2-0

Win %

ROI

-100%

Units

-2.0

Moneyline

0-2-0

Win %

ROI

-100%

Units

-2.0

Over Rate

0-2-0

Win %

ROI

-100%

Units

-2.0

Venue Splits

Cardinals Home

1-0-0 ATS

100% • +90.91%

1-0-0 ML (100%)

Hokies Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Cardinals

PPG

9.5

allowed

Total

40.5

Avg

games

Hokies

9.5

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/012025-11-01	Cardinals @ Hokies	W 16-28	-10	✓	W	U
11/042023-11-04	Hokies @ Cardinals	W 34-3	-8.5	✓	W	U

Frequently Asked Questions

What is the Louisville Cardinals vs Virginia Tech Hokies all-time record?

The Louisville Cardinals are 2-0 against the Virginia Tech Hokies in head-to-head matchups.

What is the Louisville Cardinals ATS record vs the Virginia Tech Hokies?

The Louisville Cardinals are 2-0-0 against the spread vs the Virginia Tech Hokies on DraftKings, with +91.75% ROI.

Do Louisville Cardinals vs Virginia Tech Hokies games go over or under?

Louisville Cardinals vs Virginia Tech Hokies games average 40.5 total points. The Over has hit 0% of the time.

More Cardinals Matchups

See from Hokies perspective

Head-to-head betting record for Louisville Cardinals vs Virginia Tech Hokies on LineTerminal. The Cardinals are 2-0 straight up against the Hokies and 2-0-0 against the spread (100% cover rate, +91.75% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.