Louisville Cardinals Lead Virginia Tech Hokies 2-0 in Head-to-Head Matchups

NCAAF0-2-0 ATS (0%)Updated November 1, 2025

The Virginia Tech Hokies are 0-2 against the Louisville Cardinals in head-to-head matchups, going 0-2-0 ATS (0% cover rate) with -100% ROI. Games average 40.5 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Hokies vs Cardinals Betting Record

Against the Spread

0-2-0

Win %

ROI

-100%

Units

-2.0

Moneyline

0-2-0

Win %

ROI

-100%

Units

-2.0

Over Rate

0-2-0

Win %

ROI

-100%

Units

-2.0

From the Other Side — Cardinals vs Hokies

Against the Spread

2-0-0

Win %

100%

ROI

+91.75%

Units

+1.8

Moneyline

2-0-0

Win %

100%

ROI

+28.59%

Units

+0.6

Over Rate

0-2-0

Win %

ROI

-100%

Units

-2.0

Venue Splits

Hokies Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Cardinals Home

1-0-0 ATS

100% • +90.91%

1-0-0 ML (100%)

Scoring Averages

Hokies

9.5

PPG

allowed

Total

40.5

Avg

games

Cardinals

PPG

9.5

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/012025-11-01	Cardinals @ Hokies	L 16-28	-10	✗	L	U
11/042023-11-04	Hokies @ Cardinals	L 34-3	-8.5	✗	L	U

Frequently Asked Questions

What is the Virginia Tech Hokies vs Louisville Cardinals all-time record?

The Virginia Tech Hokies are 0-2 against the Louisville Cardinals in head-to-head matchups.

What is the Virginia Tech Hokies ATS record vs the Louisville Cardinals?

The Virginia Tech Hokies are 0-2-0 against the spread vs the Louisville Cardinals on DraftKings, with -100% ROI.

Do Virginia Tech Hokies vs Louisville Cardinals games go over or under?

Virginia Tech Hokies vs Louisville Cardinals games average 40.5 total points. The Over has hit 0% of the time.

More Hokies Matchups

See from Cardinals perspective

Head-to-head betting record for Virginia Tech Hokies vs Louisville Cardinals on LineTerminal. The Hokies are 0-2 straight up against the Cardinals and 0-2-0 against the spread (0% cover rate, -100% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.