Louisville Cardinals Lead Virginia Cavaliers 3-1 in Head-to-Head Matchups

NCAAF1-3-0 ATS (25%)Updated October 4, 2025

The Louisville Cardinals are 3-1 against the Virginia Cavaliers in head-to-head matchups, going 1-3-0 ATS (25% cover rate) with -52.27% ROI. Games average 51.8 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cardinals vs Cavaliers Betting Record

Against the Spread

1-3-0

Win %

25%

ROI

-52.27%

Units

-2.1

Moneyline

3-1-0

Win %

75%

ROI

+11.27%

Units

+0.5

Over Rate

2-2-0

Win %

50%

ROI

-4.95%

Units

-0.2

From the Other Side — Cavaliers vs Cardinals

Against the Spread

3-1-0

Win %

75%

ROI

+43.86%

Units

+1.8

Moneyline

1-3-0

Win %

25%

ROI

-26.25%

Units

-1.1

Over Rate

2-2-0

Win %

50%

ROI

-4.95%

Units

-0.2

Venue Splits

Cardinals Home

0-2-0 ATS

0% • -100%

1-1-0 ML (50%)

Cavaliers Home

1-1-0 ATS

50% • -2.38%

0-2-0 ML (0%)

Scoring Averages

Cardinals

PPG

22.8

allowed

Total

51.8

Avg

games

Cavaliers

22.8

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
10/042025-10-04	Cavaliers @ Cardinals	L 27-30	-6.5	✗	L	U
10/122024-10-12	Cardinals @ Cavaliers	W 20-24	-7	✗	W	U
11/092023-11-09	Cavaliers @ Cardinals	W 31-24	-20	✗	W	O
10/082022-10-08	Cardinals @ Cavaliers	W 17-34	-1.5	✓	W	O

Frequently Asked Questions

What is the Louisville Cardinals vs Virginia Cavaliers all-time record?

The Louisville Cardinals are 3-1 against the Virginia Cavaliers in head-to-head matchups.

What is the Louisville Cardinals ATS record vs the Virginia Cavaliers?

The Louisville Cardinals are 1-3-0 against the spread vs the Virginia Cavaliers on DraftKings, with -52.27% ROI.

Do Louisville Cardinals vs Virginia Cavaliers games go over or under?

Louisville Cardinals vs Virginia Cavaliers games average 51.8 total points. The Over has hit 50% of the time.

More Cardinals Matchups

See from Cavaliers perspective

Head-to-head betting record for Louisville Cardinals vs Virginia Cavaliers on LineTerminal. The Cardinals are 3-1 straight up against the Cavaliers and 1-3-0 against the spread (25% cover rate, -52.27% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.