Louisville Cardinals Lead Virginia Cavaliers 3-1 in Head-to-Head Matchups

NCAAF3-1-0 ATS (75%)Updated October 4, 2025

The Virginia Cavaliers are 1-3 against the Louisville Cardinals in head-to-head matchups, going 3-1-0 ATS (75% cover rate) with +43.86% ROI. Games average 51.8 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cavaliers vs Cardinals Betting Record

Against the Spread

3-1-0

Win %

75%

ROI

+43.86%

Units

+1.8

Moneyline

1-3-0

Win %

25%

ROI

-26.25%

Units

-1.1

Over Rate

2-2-0

Win %

50%

ROI

-4.95%

Units

-0.2

From the Other Side — Cardinals vs Cavaliers

Against the Spread

1-3-0

Win %

25%

ROI

-52.27%

Units

-2.1

Moneyline

3-1-0

Win %

75%

ROI

+11.27%

Units

+0.5

Over Rate

2-2-0

Win %

50%

ROI

-4.95%

Units

-0.2

Venue Splits

Cavaliers Home

1-1-0 ATS

50% • -2.38%

0-2-0 ML (0%)

Cardinals Home

0-2-0 ATS

0% • -100%

1-1-0 ML (50%)

Scoring Averages

Cavaliers

22.8

PPG

allowed

Total

51.8

Avg

games

Cardinals

PPG

22.8

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
10/042025-10-04	Cavaliers @ Cardinals	W 27-30	-6.5	✓	W	U
10/122024-10-12	Cardinals @ Cavaliers	L 20-24	-7	✓	L	U
11/092023-11-09	Cavaliers @ Cardinals	L 31-24	-20	✓	L	O
10/082022-10-08	Cardinals @ Cavaliers	L 17-34	-1.5	✗	L	O

Frequently Asked Questions

What is the Virginia Cavaliers vs Louisville Cardinals all-time record?

The Virginia Cavaliers are 1-3 against the Louisville Cardinals in head-to-head matchups.

What is the Virginia Cavaliers ATS record vs the Louisville Cardinals?

The Virginia Cavaliers are 3-1-0 against the spread vs the Louisville Cardinals on DraftKings, with +43.86% ROI.

Do Virginia Cavaliers vs Louisville Cardinals games go over or under?

Virginia Cavaliers vs Louisville Cardinals games average 51.8 total points. The Over has hit 50% of the time.

More Cavaliers Matchups

See from Cardinals perspective

Head-to-head betting record for Virginia Cavaliers vs Louisville Cardinals on LineTerminal. The Cavaliers are 1-3 straight up against the Cardinals and 3-1-0 against the spread (75% cover rate, +43.86% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.