San Diego Padres Lead San Francisco Giants 10-3 in Head-to-Head Matchups (2025)

MLB3-10-0 ATS (23.08%)Data through 2025-08-21

Giants vs Padres Betting Record — 2025

Against the Spread
3-10-0
Win %
23.08%
ROI
-64.65%
Units
-8.4
Moneyline
3-10-0
Win %
23.08%
ROI
-53.75%
Units
-7.0
Over Rate
6-7-0
Win %
46.15%
ROI
-8.78%
Units
-1.1

From the Other Side — Padres vs Giants

Against the Spread
10-3-0
Win %
76.92%
ROI
+56.52%
Units
+7.3
Moneyline
10-3-0
Win %
76.92%
ROI
+45.69%
Units
+5.9
Over Rate
6-7-0
Win %
46.15%
ROI
-8.78%
Units
-1.1

Venue Splits

Giants Home
2-5-0 ATS
28.57% • -56.52%
2-5-0 ML (28.57%)
Padres Home
5-1-0 ATS
83.33% • +80.02%
5-1-0 ML (83.33%)

Scoring Averages

Giants
2.4
PPG
5.2
allowed
Total
7.5
Avg
13
games
Padres
5.2
PPG
2.4
allowed

Recent Matchups (2025)

DateScoreATSMLO/U
08/21L 8-4LO
08/20L 8-1LO
08/19L 5-1LU
08/18W 3-4WU
08/13L 1-11LO
08/12L 1-5LU
08/11L 1-4LU
06/05W 3-2WU
06/04W 6-5WO
06/03L 2-3LU
06/02L 0-1LU
04/30L 5-3LO
04/29L 7-4LO

Frequently Asked Questions

What is the San Francisco Giants vs San Diego Padres all-time record?
The San Francisco Giants are 3-10 against the San Diego Padres in 2025 in head-to-head matchups.
What is the San Francisco Giants ATS record vs the San Diego Padres?
The San Francisco Giants are 3-10-0 against the spread vs the San Diego Padres in 2025 on DraftKings, with -64.65% ROI.
Do San Francisco Giants vs San Diego Padres games go over or under?
San Francisco Giants vs San Diego Padres games average 7.5 total points in 2025. The Over has hit 46.15% of the time.

More Giants Matchups

Head-to-head betting record for San Francisco Giants vs San Diego Padres in the 2025 season on LineTerminal. The Giants are 3-10 straight up against the Padres and 3-10-0 against the spread (23.08% cover rate, -64.65% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

LineTerminal

AI-powered betting intelligence for NBA, NHL, MLB, and NCAAB.

LineTerminal provides sports data and analytics for informational and entertainment purposes only. LineTerminal does not accept, place, or facilitate bets or wagers of any kind. Odds data is sourced from third-party providers and may not reflect exact lines at every sportsbook. Past performance does not guarantee future results. Sports betting involves risk — never wager more than you can afford to lose.

If you or someone you know has a gambling problem, call 1-800-MY-RESET (National Problem Gambling Helpline) or visit ncpgambling.org. Must be 21+ in most jurisdictions. Please gamble responsibly.

© 2026 LineTerminal. All rights reserved.