San Diego Padres Lead San Francisco Giants 10-3 in Head-to-Head Matchups (2025)

MLB10-3-0 ATS (76.92%)Data through 2025-08-21

Padres vs Giants Betting Record — 2025

Against the Spread
10-3-0
Win %
76.92%
ROI
+56.52%
Units
+7.3
Moneyline
10-3-0
Win %
76.92%
ROI
+45.69%
Units
+5.9
Over Rate
6-7-0
Win %
46.15%
ROI
-8.78%
Units
-1.1

From the Other Side — Giants vs Padres

Against the Spread
3-10-0
Win %
23.08%
ROI
-64.65%
Units
-8.4
Moneyline
3-10-0
Win %
23.08%
ROI
-53.75%
Units
-7.0
Over Rate
6-7-0
Win %
46.15%
ROI
-8.78%
Units
-1.1

Venue Splits

Padres Home
5-1-0 ATS
83.33% • +80.02%
5-1-0 ML (83.33%)
Giants Home
2-5-0 ATS
28.57% • -56.52%
2-5-0 ML (28.57%)

Scoring Averages

Padres
5.2
PPG
2.4
allowed
Total
7.5
Avg
13
games
Giants
2.4
PPG
5.2
allowed

Recent Matchups (2025)

DateScoreATSMLO/U
08/21W 8-4WO
08/20W 8-1WO
08/19W 5-1WU
08/18L 3-4LU
08/13W 1-11WO
08/12W 1-5WU
08/11W 1-4WU
06/05L 3-2LU
06/04L 6-5LO
06/03W 2-3WU
06/02W 0-1WU
04/30W 5-3WO
04/29W 7-4WO

Frequently Asked Questions

What is the San Diego Padres vs San Francisco Giants all-time record?
The San Diego Padres are 10-3 against the San Francisco Giants in 2025 in head-to-head matchups.
What is the San Diego Padres ATS record vs the San Francisco Giants?
The San Diego Padres are 10-3-0 against the spread vs the San Francisco Giants in 2025 on DraftKings, with +56.52% ROI.
Do San Diego Padres vs San Francisco Giants games go over or under?
San Diego Padres vs San Francisco Giants games average 7.5 total points in 2025. The Over has hit 46.15% of the time.

More Padres Matchups

Head-to-head betting record for San Diego Padres vs San Francisco Giants in the 2025 season on LineTerminal. The Padres are 10-3 straight up against the Giants and 10-3-0 against the spread (76.92% cover rate, +56.52% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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