St. Louis Cardinals Lead Cincinnati Reds 7-6 in Head-to-Head Matchups (2025)

MLB7-6-0 ATS (53.85%)Data through 2025-09-17

Reds vs Cardinals Betting Record — 2025

Against the Spread
7-6-0
Win %
53.85%
ROI
+12.72%
Units
+1.6
Moneyline
6-7-0
Win %
46.15%
ROI
-15.05%
Units
-2.0
Over Rate
6-7-0
Win %
46.15%
ROI
-11.83%
Units
-1.5

From the Other Side — Cardinals vs Reds

Against the Spread
6-7-0
Win %
46.15%
ROI
-12.58%
Units
-1.6
Moneyline
7-6-0
Win %
53.85%
ROI
+5.15%
Units
+0.7
Over Rate
6-7-0
Win %
46.15%
ROI
-11.83%
Units
-1.5

Venue Splits

Reds Home
3-4-0 ATS
42.86% • -19.96%
3-4-0 ML (42.86%)
Cardinals Home
2-4-0 ATS
33.33% • -31.97%
3-3-0 ML (50%)

Scoring Averages

Reds
4.2
PPG
4.3
allowed
Total
8.5
Avg
13
games
Cardinals
4.3
PPG
4.2
allowed

Recent Matchups (2025)

DateScoreATSMLO/U
09/17W 2-6WU
09/16L 3-0LU
09/15W 6-11WO
08/31W 7-4WO
08/30L 2-4LU
08/29L 5-7LO
06/22W 1-4WU
06/21L 6-5LO
06/20L 6-1LU
05/01W 9-1WO
04/30L 1-9LO
04/30L 0-6LU
04/28W 3-1WU

Frequently Asked Questions

What is the Cincinnati Reds vs St. Louis Cardinals all-time record?
The Cincinnati Reds are 6-7 against the St. Louis Cardinals in 2025 in head-to-head matchups.
What is the Cincinnati Reds ATS record vs the St. Louis Cardinals?
The Cincinnati Reds are 7-6-0 against the spread vs the St. Louis Cardinals in 2025 on DraftKings, with +12.72% ROI.
Do Cincinnati Reds vs St. Louis Cardinals games go over or under?
Cincinnati Reds vs St. Louis Cardinals games average 8.5 total points in 2025. The Over has hit 46.15% of the time.

More Reds Matchups

Head-to-head betting record for Cincinnati Reds vs St. Louis Cardinals in the 2025 season on LineTerminal. The Reds are 6-7 straight up against the Cardinals and 7-6-0 against the spread (53.85% cover rate, +12.72% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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