St. Louis Cardinals Lead Cincinnati Reds 46-38 in Head-to-Head Matchups

MLB35-30-0 ATS (53.85%)Data through 2025-09-17

Reds vs Cardinals Betting Record

Against the Spread
35-30-0
Win %
53.85%
ROI
+4.84%
Units
+3.1
Moneyline
36-45-0
Win %
44.44%
ROI
-6.32%
Units
-5.1
Over Rate
27-38-0
Win %
41.54%
ROI
-20.88%
Units
-13.6

From the Other Side — Cardinals vs Reds

Against the Spread
30-35-0
Win %
46.15%
ROI
-11.19%
Units
-7.3
Moneyline
45-36-0
Win %
55.56%
ROI
+2.98%
Units
+2.4
Over Rate
27-38-0
Win %
41.54%
ROI
-20.88%
Units
-13.6

Venue Splits

Reds Home
17-16-0 ATS
51.52% • +0.06%
17-19-0 ML (47.22%)
Cardinals Home
14-18-0 ATS
43.75% • -11.72%
26-19-0 ML (57.78%)

Scoring Averages

Reds
4.3
PPG
4.5
allowed
Total
8.8
Avg
84
games
Cardinals
4.5
PPG
4.3
allowed

Recent Matchups

DateScoreATSMLO/U
09/17W 2-6WU
09/16L 3-0LU
09/15W 6-11WO
08/31W 7-4WO
08/30L 2-4LU
08/29L 5-7LO
06/22W 1-4WU
06/21L 6-5LO
06/20L 6-1LU
05/01W 9-1WO
04/30L 0-6LU
04/30L 1-9LO
04/28W 3-1WU
09/12L 6-1LU
09/11L 2-1LU
09/10W 0-3WU
08/14W 9-2WO
08/13W 4-1WU
08/12W 6-1WU
06/30L 2-0LU

Frequently Asked Questions

What is the Cincinnati Reds vs St. Louis Cardinals all-time record?
The Cincinnati Reds are 38-46 against the St. Louis Cardinals in head-to-head matchups.
What is the Cincinnati Reds ATS record vs the St. Louis Cardinals?
The Cincinnati Reds are 35-30-0 against the spread vs the St. Louis Cardinals on DraftKings, with +4.84% ROI.
Do Cincinnati Reds vs St. Louis Cardinals games go over or under?
Cincinnati Reds vs St. Louis Cardinals games average 8.8 total points. The Over has hit 41.54% of the time.

More Reds Matchups

Head-to-head betting record for Cincinnati Reds vs St. Louis Cardinals on LineTerminal. The Reds are 38-46 straight up against the Cardinals and 35-30-0 against the spread (53.85% cover rate, +4.84% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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