Cleveland Guardians Lead Chicago White Sox 11-2 in Head-to-Head Matchups (2025)

MLB6-7-0 ATS (46.15%)Data through 2025-09-14

White Sox vs Guardians Betting Record — 2025

Against the Spread
6-7-0
Win %
46.15%
ROI
-22.97%
Units
-3.0
Moneyline
2-11-0
Win %
15.38%
ROI
-68%
Units
-8.8
Over Rate
4-9-0
Win %
30.77%
ROI
-41.59%
Units
-5.4

From the Other Side — Guardians vs White Sox

Against the Spread
7-6-0
Win %
53.85%
ROI
+17.07%
Units
+2.2
Moneyline
11-2-0
Win %
84.62%
ROI
+39.08%
Units
+5.1
Over Rate
4-9-0
Win %
30.77%
ROI
-41.59%
Units
-5.4

Venue Splits

White Sox Home
3-4-0 ATS
42.86% • -29%
2-5-0 ML (28.57%)
Guardians Home
3-3-0 ATS
50% • +7.66%
6-0-0 ML (100%)

Scoring Averages

White Sox
2.5
PPG
4.3
allowed
Total
6.8
Avg
13
games
Guardians
4.3
PPG
2.5
allowed

Recent Matchups (2025)

DateScoreATSMLO/U
09/14L 3-2LU
09/13L 3-1LU
09/12L 4-0LU
08/10W 6-4WO
08/09L 1-3LU
08/08L 5-9LO
07/13L 5-6LO
07/12L 2-6LU
07/11W 5-4WO
07/11L 2-4LU
04/10L 6-1LU
04/09L 3-2LU
04/08L 1-0LU

Frequently Asked Questions

What is the Chicago White Sox vs Cleveland Guardians all-time record?
The Chicago White Sox are 2-11 against the Cleveland Guardians in 2025 in head-to-head matchups.
What is the Chicago White Sox ATS record vs the Cleveland Guardians?
The Chicago White Sox are 6-7-0 against the spread vs the Cleveland Guardians in 2025 on DraftKings, with -22.97% ROI.
Do Chicago White Sox vs Cleveland Guardians games go over or under?
Chicago White Sox vs Cleveland Guardians games average 6.8 total points in 2025. The Over has hit 30.77% of the time.

More White Sox Matchups

Head-to-head betting record for Chicago White Sox vs Cleveland Guardians in the 2025 season on LineTerminal. The White Sox are 2-11 straight up against the Guardians and 6-7-0 against the spread (46.15% cover rate, -22.97% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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