Penn State Nittany Lions Lead Indiana Hoosiers 2-1 in Head-to-Head Matchups

NCAAF2-1-0 ATS (66.67%)Updated November 8, 2025

The Penn State Nittany Lions are 2-1 against the Indiana Hoosiers in head-to-head matchups, going 2-1-0 ATS (66.67% cover rate) with +27.4% ROI. Games average 55.7 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Nittany Lions vs Hoosiers Betting Record

Against the Spread

2-1-0

Win %

66.67%

ROI

+27.4%

Units

+0.8

Moneyline

2-1-0

Win %

66.67%

ROI

-26.96%

Units

-0.8

Over Rate

3-0-0

Win %

100%

ROI

+90.93%

Units

+2.7

From the Other Side — Hoosiers vs Nittany Lions

Against the Spread

1-2-0

Win %

33.33%

ROI

-36.9%

Units

-1.1

Moneyline

1-2-0

Win %

33.33%

ROI

-61.11%

Units

-1.8

Over Rate

3-0-0

Win %

100%

ROI

+90.93%

Units

+2.7

Venue Splits

Nittany Lions Home

1-1-0 ATS

50% • -6.52%

1-1-0 ML (50%)

Hoosiers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Nittany Lions

PPG

21.7

allowed

Total

55.7

Avg

games

Hoosiers

21.7

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/082025-11-08	Hoosiers @ Nittany Lions	L 24-27	-14.5	✓	L	O
10/282023-10-28	Hoosiers @ Nittany Lions	W 33-24	-31	✗	W	O
11/052022-11-05	Nittany Lions @ Hoosiers	W 14-45	-14	✓	W	O

Frequently Asked Questions

What is the Penn State Nittany Lions vs Indiana Hoosiers all-time record?

The Penn State Nittany Lions are 2-1 against the Indiana Hoosiers in head-to-head matchups.

What is the Penn State Nittany Lions ATS record vs the Indiana Hoosiers?

The Penn State Nittany Lions are 2-1-0 against the spread vs the Indiana Hoosiers on DraftKings, with +27.4% ROI.

Do Penn State Nittany Lions vs Indiana Hoosiers games go over or under?

Penn State Nittany Lions vs Indiana Hoosiers games average 55.7 total points. The Over has hit 100% of the time.

More Nittany Lions Matchups

See from Hoosiers perspective

Head-to-head betting record for Penn State Nittany Lions vs Indiana Hoosiers on LineTerminal. The Nittany Lions are 2-1 straight up against the Hoosiers and 2-1-0 against the spread (66.67% cover rate, +27.4% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.