Duke Blue Devils Lead Clemson Tigers 2-0 in Head-to-Head Matchups

NCAAF2-0-0 ATS (100%)Updated November 1, 2025

The Duke Blue Devils are 2-0 against the Clemson Tigers in head-to-head matchups, going 2-0-0 ATS (100% cover rate) with +90.1% ROI. Games average 63 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Duke Blue Devils vs Clemson Tigers Betting Record

Against the Spread

2-0-0

Win %

100%

ROI

+90.1%

Units

+1.8

Moneyline

2-0-0

Win %

100%

ROI

+250%

Units

+5.0

Over Rate

1-1-0

Win %

50%

ROI

-6.52%

Units

-0.1

From the Other Side — Clemson Tigers vs Duke Blue Devils

Against the Spread

0-2-0

Win %

ROI

-100%

Units

-2.0

Moneyline

0-2-0

Win %

ROI

-100%

Units

-2.0

Over Rate

1-1-0

Win %

50%

ROI

-6.52%

Units

-0.1

Venue Splits

Duke Blue Devils Home

1-0-0 ATS

100% • +90.91%

1-0-0 ML (100%)

Clemson Tigers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Duke Blue Devils

PPG

allowed

Total

Avg

games

Clemson Tigers

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/012025-11-01	Duke Blue Devils @ Clemson Tigers	W 45-46	-4	✓	W	O
09/042023-09-04	Clemson Tigers @ Duke Blue Devils	W 28-7	-12	✓	W	U

Frequently Asked Questions

What is the Duke Blue Devils vs Clemson Tigers all-time record?

The Duke Blue Devils are 2-0 against the Clemson Tigers in head-to-head matchups.

What is the Duke Blue Devils ATS record vs the Clemson Tigers?

The Duke Blue Devils are 2-0-0 against the spread vs the Clemson Tigers on DraftKings, with +90.1% ROI.

Do Duke Blue Devils vs Clemson Tigers games go over or under?

Duke Blue Devils vs Clemson Tigers games average 63 total points. The Over has hit 50% of the time.

More Duke Blue Devils Matchups

vs Boston College Eagles

vs California Golden Bears

vs Florida State Seminoles

vs Georgia Tech Yellow Jackets

vs Louisville Cardinals

vs Miami Hurricanes

See from Clemson Tigers perspective

Head-to-head betting record for Duke Blue Devils vs Clemson Tigers on LineTerminal. The Duke Blue Devils are 2-0 straight up against the Clemson Tigers and 2-0-0 against the spread (100% cover rate, +90.1% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.