Louisville Cardinals Lead Notre Dame Fighting Irish 1-0 in Head-to-Head Matchups (2025-26)

NCAAB1-0-0 ATS (100%)

The Notre Dame Fighting Irish are 0-1 against the Louisville Cardinals in 2025-26 in head-to-head matchups, going 1-0-0 ATS (100% cover rate) with +95.24% ROI. Games average 141 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAB box scores.

See methodology.

Notre Dame Fighting Irish vs Louisville Cardinals Betting Record — 2025-26

Against the Spread
1-0-0
Win %
100%
ROI
+95.24%
Units
+0.9
Moneyline
0-1-0
Win %
0%
ROI
-100%
Units
-1.0
Over Rate
0-1-0
Win %
0%
ROI
-100%
Units
-1.0

From the Other Side — Louisville Cardinals vs Notre Dame Fighting Irish

Against the Spread
0-1-0
Win %
0%
ROI
-100%
Units
-1.0
Moneyline
1-0-0
Win %
100%
ROI
+4.17%
Units
+0.0
Over Rate
0-1-0
Win %
0%
ROI
-100%
Units
-1.0

Venue Splits

Notre Dame Fighting Irish Home
Louisville Cardinals Home
0-1-0 ATS
0% • -100%
1-0-0 ML (100%)

Scoring Averages

Notre Dame Fighting Irish
65
PPG
76
allowed
Total
141
Avg
1
games
Louisville Cardinals
76
PPG
65
allowed

Recent Matchups (2025-26)

DateScoreATSMLO/U
02/04L 76-65LU

Frequently Asked Questions

What is the Notre Dame Fighting Irish vs Louisville Cardinals 2025-26 record?
The Notre Dame Fighting Irish are 0-1 against the Louisville Cardinals in 2025-26 in head-to-head matchups.
What is the Notre Dame Fighting Irish ATS record vs the Louisville Cardinals?
The Notre Dame Fighting Irish are 1-0-0 against the spread vs the Louisville Cardinals in 2025-26 on DraftKings, with +95.24% ROI.
Do Notre Dame Fighting Irish vs Louisville Cardinals games go over or under?
Notre Dame Fighting Irish vs Louisville Cardinals games average 141 total points in 2025-26. The Over has hit 0% of the time.

More Notre Dame Fighting Irish Matchups

Head-to-head betting record for Notre Dame Fighting Irish vs Louisville Cardinals in the 2025-26 season on LineTerminal. The Notre Dame Fighting Irish are 0-1 straight up against the Louisville Cardinals and 1-0-0 against the spread (100% cover rate, +95.24% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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