Notre Dame Fighting IrishAway65
Louisville CardinalsHome76SpreadCoverFav -18.5
MoneylineLoss
TotalUnder155.5
NCAAB · Head to head
Notre Dame Fighting Irish vs Louisville Cardinals
All recorded seasonsLast meeting Feb 4, 2026
Betting comparison
All seasons
Notre Dame Fighting Irish
6 bets4-2-0Wins · Losses · Pushes
- Win rate
- 66.67%
- ROI
- +27.62%
- Units
- +1.66u
Louisville Cardinals
6 bets2-4-0Wins · Losses · Pushes
- Win rate
- 33.33%
- ROI
- -36.3%
- Units
- -2.18u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsNotre Dame Fighting Irish69.7
Louisville Cardinals65
Combined134.7
Recent meetings
Bet results from the Notre Dame Fighting Irish perspective. Spread values show the favorite’s closing line.
Notre Dame Fighting IrishAway65Louisville CardinalsHome76Louisville CardinalsAway75Notre Dame Fighting IrishHome60SpreadMissFav -7.5
MoneylineLoss
TotalUnder148.5
Notre Dame Fighting IrishAway72Louisville CardinalsHome50SpreadCoverFav -3
MoneylineWin
TotalUnder136.5
Louisville CardinalsAway62Notre Dame Fighting IrishHome76SpreadCoverFav -9
MoneylineWin
TotalPush138
Louisville CardinalsAway57Notre Dame Fighting IrishHome63SpreadMissFav -6.5
MoneylineWin
TotalUnder134.5
More Notre Dame Fighting Irish matchups
About this matchup
What is the Notre Dame Fighting Irish vs Louisville Cardinals all-time record?
The Notre Dame Fighting Irish are 4-2 against the Louisville Cardinals in head-to-head matchups.
What is the Notre Dame Fighting Irish ATS record vs the Louisville Cardinals?
The Notre Dame Fighting Irish are 4-2-0 against the spread vs the Louisville Cardinals on DraftKings, with +27.62% ROI.
Do Notre Dame Fighting Irish vs Louisville Cardinals games go over or under?
Notre Dame Fighting Irish vs Louisville Cardinals games average 134.7 total points. The Over has hit 0% of the time.