Louisville CardinalsAway75
Clemson TigersHome80SpreadMissFav -1.5
MoneylineLoss
TotalOver146.5
NCAAB · Head to head
Louisville Cardinals vs Clemson Tigers
All recorded seasonsLast meeting Feb 28, 2026
Betting comparison
All seasons
Louisville Cardinals
7 bets6-1-0Wins · Losses · Pushes
- Win rate
- 85.71%
- ROI
- +62.99%
- Units
- +4.41u
Clemson Tigers
7 bets1-6-0Wins · Losses · Pushes
- Win rate
- 14.29%
- ROI
- -71.71%
- Units
- -5.02u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsLouisville Cardinals73.1
Clemson Tigers72
Combined145.1
Recent meetings
Bet results from the Louisville Cardinals perspective. Spread values show the favorite’s closing line.
Louisville CardinalsAway75Clemson TigersHome80Clemson TigersAway73Louisville CardinalsHome76SpreadCoverFav -2.5
MoneylineWin
TotalOver141.5
Clemson TigersAway64Louisville CardinalsHome74SpreadCoverFav -3.5
MoneylineWin
TotalUnder147.5
Louisville CardinalsAway64Clemson TigersHome70SpreadCoverFav -16
MoneylineLoss
TotalUnder150
Clemson TigersAway73Louisville CardinalsHome83SpreadCoverFav -11
MoneylineWin
TotalOver140.5
More Louisville Cardinals matchups
About this matchup
What is the Louisville Cardinals vs Clemson Tigers all-time record?
The Louisville Cardinals are 4-3 against the Clemson Tigers in head-to-head matchups.
What is the Louisville Cardinals ATS record vs the Clemson Tigers?
The Louisville Cardinals are 6-1-0 against the spread vs the Clemson Tigers on DraftKings, with +62.99% ROI.
Do Louisville Cardinals vs Clemson Tigers games go over or under?
Louisville Cardinals vs Clemson Tigers games average 145.1 total points. The Over has hit 57.14% of the time.