Louisville CardinalsAway75
Clemson TigersHome80SpreadCoverFav -1.5
MoneylineWin
TotalOver146.5
NCAAB · Head to head
Clemson Tigers vs Louisville Cardinals
All recorded seasonsLast meeting Feb 28, 2026
Betting comparison
All seasons
Clemson Tigers
7 bets1-6-0Wins · Losses · Pushes
- Win rate
- 14.29%
- ROI
- -71.71%
- Units
- -5.02u
Louisville Cardinals
7 bets6-1-0Wins · Losses · Pushes
- Win rate
- 85.71%
- ROI
- +62.99%
- Units
- +4.41u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsClemson Tigers72
Louisville Cardinals73.1
Combined145.1
Recent meetings
Bet results from the Clemson Tigers perspective. Spread values show the favorite’s closing line.
Louisville CardinalsAway75Clemson TigersHome80Clemson TigersAway73Louisville CardinalsHome76SpreadMissFav -2.5
MoneylineLoss
TotalOver141.5
Clemson TigersAway64Louisville CardinalsHome74SpreadMissFav -3.5
MoneylineLoss
TotalUnder147.5
Louisville CardinalsAway64Clemson TigersHome70SpreadMissFav -16
MoneylineWin
TotalUnder150
Clemson TigersAway73Louisville CardinalsHome83SpreadMissFav -11
MoneylineLoss
TotalOver140.5
More Clemson Tigers matchups
About this matchup
What is the Clemson Tigers vs Louisville Cardinals all-time record?
The Clemson Tigers are 3-4 against the Louisville Cardinals in head-to-head matchups.
What is the Clemson Tigers ATS record vs the Louisville Cardinals?
The Clemson Tigers are 1-6-0 against the spread vs the Louisville Cardinals on DraftKings, with -71.71% ROI.
Do Clemson Tigers vs Louisville Cardinals games go over or under?
Clemson Tigers vs Louisville Cardinals games average 145.1 total points. The Over has hit 57.14% of the time.