Inside Edge
The St. Louis Cardinals are 22-43-0 ATS as Favorites in 2025
MLBNational • NL Central
The St. Louis Cardinals are 22-43-0 as favorite in 2025, a 33.85% rate with -20.59% ROI on flat $100 bets at closing odds. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official MLB box scores.
Favorite ATS
22-43-0
Win %
33.85%
ROI
-20.59%
Games
65
Favorite ML
32-33-0
Win %
49.23%
ROI
-15.22%
Games
65
Cardinals Monthly Performance
-8.9%81-81 · -14.4u
+17.1%
-21.3%
+43.2%
-9.8%
-25.1%
-22.9%
-24.6%
Mar
3-1
3-1
Apr
12-15
12-15
May
20-7
20-7
Jun
13-15
13-15
Jul
10-14
10-14
Aug
12-16
12-16
Sep
11-13
11-13
Home / Away as Favorite ATS
Home
9-24-0
27.27%-35.43%
Away
13-19-0
40.63%-5.29%
Recent Games (2025)
| Date | Opponent | Score | ATS | ML | O/U |
|---|---|---|---|---|---|
| 2025-09-28 |  @ Cubs | L 2-0 | ✗ | L | U |
| 2025-09-27 | @ Cubs | L 7-3 | ✗ | L | O |
| 2025-09-26 | @ Cubs | L 12-1 | ✗ | L | O |
| 2025-09-24 |  @ Giants | L 4-3 | ✗ | L | U |
| 2025-09-23 | @ Giants | W 8-9 | ✓ | W | O |
| 2025-09-22 | @ Giants | W 5-6 | ✓ | W | O |
| 2025-09-21 |  vs Brewers | W 5-1 | ✓ | W | U |
| 2025-09-20 | vs Brewers | L 2-3 | ✓ | L | U |
| 2025-09-19 | vs Brewers | W 7-1 | ✓ | W | O |
| 2025-09-17 |  vs Reds | L 2-6 | ✗ | L | U |
Frequently Asked Questions
What is the St. Louis Cardinals as favorite in 2025?
The St. Louis Cardinals are 22-43-0 (33.85%) as favorite in 2025 on DraftKings, with -20.59% ROI.
What is the St. Louis Cardinals home vs away as favorite?
Home: 9-24-0 (-35.43% ROI). Away: 13-19-0 (-5.29% ROI).
More Cardinals Stats (2025)
Compare As Favorite
Record as Favorite for the St. Louis Cardinals in the 2025 season on LineTerminal. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results. LineTerminal offers advanced system-building tools to research St. Louis Cardinals betting trends across 80+ filters and 5+ years of data.