San Diego Padres Lead San Francisco Giants 13-6 in Head-to-Head Matchups (2022)

MLB9-10-0 ATS (47.37%)Data through 2022-10-05

Giants vs Padres Betting Record — 2022

Against the Spread
9-10-0
Win %
47.37%
ROI
-12.57%
Units
-2.4
Moneyline
6-13-0
Win %
31.58%
ROI
-35.11%
Units
-6.7
Over Rate
12-7-0
Win %
63.16%
ROI
+20.85%
Units
+4.0

From the Other Side — Padres vs Giants

Against the Spread
10-9-0
Win %
52.63%
ROI
+1.85%
Units
+0.3
Moneyline
13-6-0
Win %
68.42%
ROI
+27.9%
Units
+5.3
Over Rate
12-7-0
Win %
63.16%
ROI
+20.85%
Units
+4.0

Venue Splits

Giants Home
4-5-0 ATS
44.44% • -29.56%
2-7-0 ML (22.22%)
Padres Home
5-5-0 ATS
50% • +14.5%
6-4-0 ML (60%)

Scoring Averages

Giants
4.4
PPG
4.5
allowed
Total
8.8
Avg
19
games
Padres
4.5
PPG
4.4
allowed

Recent Matchups (2022)

DateScoreATSMLO/U
10/05W 1-8WO
10/04L 6-2LO
10/03L 7-4LO
08/31L 4-5LO
08/30L 3-4LU
08/29L 5-6LO
08/10L 13-7LO
08/09L 7-4LO
08/08W 0-1WU
07/10W 0-12WO
07/09W 1-3WU
07/08L 6-3LO
07/07L 2-1LU
05/22L 1-10LO
05/21L 1-2LU
05/20L 7-8LO
04/13W 2-1WU
04/12W 13-2WO
04/11L 2-4LU

Frequently Asked Questions

What is the San Francisco Giants vs San Diego Padres all-time record?
The San Francisco Giants are 6-13 against the San Diego Padres in 2022 in head-to-head matchups.
What is the San Francisco Giants ATS record vs the San Diego Padres?
The San Francisco Giants are 9-10-0 against the spread vs the San Diego Padres in 2022 on DraftKings, with -12.57% ROI.
Do San Francisco Giants vs San Diego Padres games go over or under?
San Francisco Giants vs San Diego Padres games average 8.8 total points in 2022. The Over has hit 63.16% of the time.

More Giants Matchups

Head-to-head betting record for San Francisco Giants vs San Diego Padres in the 2022 season on LineTerminal. The Giants are 6-13 straight up against the Padres and 9-10-0 against the spread (47.37% cover rate, -12.57% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

LineTerminal

AI-powered betting intelligence for NBA, NHL, MLB, and NCAAB.

LineTerminal provides sports data and analytics for informational and entertainment purposes only. LineTerminal does not accept, place, or facilitate bets or wagers of any kind. Odds data is sourced from third-party providers and may not reflect exact lines at every sportsbook. Past performance does not guarantee future results. Sports betting involves risk — never wager more than you can afford to lose.

If you or someone you know has a gambling problem, call 1-800-MY-RESET (National Problem Gambling Helpline) or visit ncpgambling.org. Must be 21+ in most jurisdictions. Please gamble responsibly.

© 2026 LineTerminal. All rights reserved.