Chicago Cubs Lead Cincinnati Reds 46-43 in Head-to-Head Matchups

MLB38-35-0 ATS (52.05%)

The Chicago Cubs are 46-43 against the Cincinnati Reds in head-to-head matchups, going 38-35-0 ATS (52.05% cover rate) with +11.41% ROI. Games average 9.8 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official MLB box scores.

See methodology.

Cubs vs Reds Betting Record

Against the Spread
38-35-0
Win %
52.05%
ROI
+11.41%
Units
+8.3
Moneyline
46-43-1
Win %
51.69%
ROI
-4.12%
Units
-3.7
Over Rate
33-33-7
Win %
50%
ROI
-4.87%
Units
-3.2

From the Other Side — Reds vs Cubs

Against the Spread
35-38-0
Win %
47.95%
ROI
-17.11%
Units
-12.5
Moneyline
43-46-1
Win %
48.31%
ROI
-4.06%
Units
-3.6
Over Rate
33-33-7
Win %
50%
ROI
-4.87%
Units
-3.2

Venue Splits

Cubs Home
17-21-0 ATS
44.74% • +0.11%
26-18-0 ML (59.09%)
Reds Home
14-21-0 ATS
40% • -28.63%
25-20-1 ML (55.56%)

Scoring Averages

Cubs
5.3
PPG
4.5
allowed
Total
9.8
Avg
89
games
Reds
4.5
PPG
5.3
allowed

Recent Matchups

DateScoreATSMLO/U
07/12W 4-8WO
07/11W 3-5WU
07/10L 4-0LU
05/07W 8-3WO
05/06W 7-6WO
05/05W 3-2WU
05/04W 5-4WU
09/21L 1-0LU
09/20L 6-3LP
09/19L 7-4LO
09/18L 1-0LU
08/06W 6-1WU
08/05L 1-5LU
08/04L 2-3LU
06/01W 7-3WO
05/31W 2-0WU
05/30L 2-6LU
05/25W 8-11WO
05/24L 6-4LO
05/23W 6-13WO

Frequently Asked Questions

What is the Chicago Cubs vs Cincinnati Reds all-time record?
The Chicago Cubs are 46-43 against the Cincinnati Reds in head-to-head matchups.
What is the Chicago Cubs ATS record vs the Cincinnati Reds?
The Chicago Cubs are 38-35-0 against the spread vs the Cincinnati Reds on DraftKings, with +11.41% ROI.
Do Chicago Cubs vs Cincinnati Reds games go over or under?
Chicago Cubs vs Cincinnati Reds games average 9.8 total points. The Over has hit 50% of the time.

More Cubs Matchups

Head-to-head betting record for Chicago Cubs vs Cincinnati Reds on LineTerminal. The Cubs are 46-43 straight up against the Reds and 38-35-0 against the spread (52.05% cover rate, +11.41% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

LineTerminal

AI-powered betting intelligence for NBA, WNBA, NHL, MLB, NFL, NCAAB, and NCAAF.

LineTerminal provides sports data and analytics for informational and entertainment purposes only. LineTerminal does not accept, place, or facilitate bets or wagers of any kind. Odds data is sourced from third-party providers and may not reflect exact lines at every sportsbook. Past performance does not guarantee future results. Sports betting involves risk — never wager more than you can afford to lose.

If you or someone you know has a gambling problem, call 1-800-MY-RESET (National Problem Gambling Helpline) or visit ncpgambling.org. Must be 21+ in most jurisdictions. Please gamble responsibly.

© 2026 LineTerminal LLC. All rights reserved.