Louisville Cardinals Lead Boston College Eagles 3-1 in Head-to-Head Matchups

NCAAF3-1-0 ATS (75%)Updated October 25, 2025

The Boston College Eagles are 1-3 against the Louisville Cardinals in head-to-head matchups, going 3-1-0 ATS (75% cover rate) with +42.19% ROI. Games average 67.8 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Eagles vs Cardinals Betting Record

Against the Spread

3-1-0

Win %

75%

ROI

+42.19%

Units

+1.7

Moneyline

1-3-0

Win %

25%

ROI

+27.5%

Units

+1.1

Over Rate

4-0-0

Win %

100%

ROI

+90.91%

Units

+3.6

From the Other Side — Cardinals vs Eagles

Against the Spread

1-3-0

Win %

25%

ROI

-52.27%

Units

-2.1

Moneyline

3-1-0

Win %

75%

ROI

-9.36%

Units

-0.4

Over Rate

4-0-0

Win %

100%

ROI

+90.91%

Units

+3.6

Venue Splits

Eagles Home

2-0-0 ATS

100% • +88.93%

1-1-0 ML (50%)

Cardinals Home

1-1-0 ATS

50% • -4.55%

2-0-0 ML (100%)

Scoring Averages

Eagles

28.3

PPG

39.5

allowed

Total

67.8

Avg

games

Cardinals

39.5

PPG

28.3

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
10/252025-10-25	Eagles @ Cardinals	L 38-24	-25.5	✓	L	O
10/252024-10-25	Cardinals @ Eagles	L 27-31	-7	✓	L	O
09/232023-09-23	Eagles @ Cardinals	L 56-28	-14	✗	L	O
10/012022-10-01	Cardinals @ Eagles	W 34-33	-13.5	✓	W	O

Frequently Asked Questions

What is the Boston College Eagles vs Louisville Cardinals all-time record?

The Boston College Eagles are 1-3 against the Louisville Cardinals in head-to-head matchups.

What is the Boston College Eagles ATS record vs the Louisville Cardinals?

The Boston College Eagles are 3-1-0 against the spread vs the Louisville Cardinals on DraftKings, with +42.19% ROI.

Do Boston College Eagles vs Louisville Cardinals games go over or under?

Boston College Eagles vs Louisville Cardinals games average 67.8 total points. The Over has hit 100% of the time.

More Eagles Matchups

See from Cardinals perspective

Head-to-head betting record for Boston College Eagles vs Louisville Cardinals on LineTerminal. The Eagles are 1-3 straight up against the Cardinals and 3-1-0 against the spread (75% cover rate, +42.19% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.