San Diego Padres Lead Chicago White Sox 2-1 in Head-to-Head Matchups (2025)

MLB1-2-0 ATS (33.33%)Data through 2025-09-21

Padres vs White Sox Betting Record — 2025

Against the Spread
1-2-0
Win %
33.33%
ROI
-36.09%
Units
-1.1
Moneyline
2-1-0
Win %
66.67%
ROI
+2.51%
Units
+0.1
Over Rate
1-2-0
Win %
33.33%
ROI
-36.64%
Units
-1.1

From the Other Side — White Sox vs Padres

Against the Spread
2-1-0
Win %
66.67%
ROI
+26.9%
Units
+0.8
Moneyline
1-2-0
Win %
33.33%
ROI
-14.33%
Units
-0.4
Over Rate
1-2-0
Win %
33.33%
ROI
-36.64%
Units
-1.1

Venue Splits

Padres Home
White Sox Home
2-1-0 ATS
66.67% • +26.9%
1-2-0 ML (33.33%)

Scoring Averages

Padres
4.3
PPG
3
allowed
Total
7.3
Avg
3
games
White Sox
3
PPG
4.3
allowed

Recent Matchups (2025)

DateScoreATSMLO/U
09/21W 2-3WU
09/20W 3-7WO
09/19L 4-3LU

Frequently Asked Questions

What is the San Diego Padres vs Chicago White Sox all-time record?
The San Diego Padres are 2-1 against the Chicago White Sox in 2025 in head-to-head matchups.
What is the San Diego Padres ATS record vs the Chicago White Sox?
The San Diego Padres are 1-2-0 against the spread vs the Chicago White Sox in 2025 on DraftKings, with -36.09% ROI.
Do San Diego Padres vs Chicago White Sox games go over or under?
San Diego Padres vs Chicago White Sox games average 7.3 total points in 2025. The Over has hit 33.33% of the time.

More Padres Matchups

Head-to-head betting record for San Diego Padres vs Chicago White Sox in the 2025 season on LineTerminal. The Padres are 2-1 straight up against the White Sox and 1-2-0 against the spread (33.33% cover rate, -36.09% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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