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Baltimore Orioles Lead Chicago White Sox 21-10 in Head-to-Head Matchups

MLB6-19-0 ATS (24%)Data through 2025-09-17

White Sox vs Orioles Betting Record

Against the Spread

6-19-0

Win %

24%

ROI

-54.96%

Units

-13.7

Moneyline

10-20-0

Win %

33.33%

ROI

-35%

Units

-10.5

Over Rate

10-12-3

Win %

45.45%

ROI

-13.99%

Units

-3.1

From the Other Side — Orioles vs White Sox

Against the Spread

19-6-0

Win %

76%

ROI

+38.51%

Units

+9.6

Moneyline

20-10-0

Win %

66.67%

ROI

+17.17%

Units

+5.2

Over Rate

10-12-3

Win %

45.45%

ROI

-13.99%

Units

-3.1

Venue Splits

White Sox Home

2-11-0 ATS

15.38% • -76.36%

4-11-0 ML (26.67%)

Orioles Home

8-4-0 ATS

66.67% • +13.71%

9-6-0 ML (60%)

Scoring Averages

White Sox

3.8

PPG

4.9

allowed

Total

8.8

Avg

31

games

Orioles

4.9

PPG

3.8

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
09/172025-09-17	Orioles @ White Sox	L 1-3	-1.5	✗	L	U
09/162025-09-16	Orioles @ White Sox	L 7-8	-1.5	✓	L	O
09/152025-09-15	Orioles @ White Sox	L 1-4	-1.5	✗	L	U
06/012025-06-01	White Sox @ Orioles	L 3-2	-1.5	✓	L	U
05/312025-05-31	White Sox @ Orioles	L 4-2	-1.5	✗	L	U
05/302025-05-30	White Sox @ Orioles	L 2-1	-1.5	✗	L	U
09/042024-09-04	White Sox @ Orioles	W 1-8	-1.5	✓	W	O
09/032024-09-03	White Sox @ Orioles	L 9-0	-1.5	✗	L	P
09/022024-09-02	White Sox @ Orioles	L 13-3	-2.5	✗	L	O
05/262024-05-26	Orioles @ White Sox	L 1-4	-1.5	✗	L	U
05/252024-05-25	Orioles @ White Sox	L 3-5	-	-	-	-
05/242024-05-24	Orioles @ White Sox	L 4-6	-1.5	✗	L	O
05/232024-05-23	Orioles @ White Sox	L 6-8	-1.5	✗	L	O
08/302023-08-30	White Sox @ Orioles	W 5-10	-1.5	✓	W	O
08/292023-08-29	White Sox @ Orioles	L 9-3	-1.5	✗	L	O
08/282023-08-28	White Sox @ Orioles	L 9-0	-1.5	✗	L	P
04/162023-04-16	Orioles @ White Sox	L 4-8	-1.5	✗	L	O
04/152023-04-15	Orioles @ White Sox	W 7-6	-1.5	✓	W	O
04/142023-04-14	Orioles @ White Sox	L 3-6	-1.5	✗	L	P
08/252022-08-25	White Sox @ Orioles	L 4-3	-1.5	✗	L	U

Frequently Asked Questions

What is the Chicago White Sox vs Baltimore Orioles all-time record?

The Chicago White Sox are 10-21 against the Baltimore Orioles in head-to-head matchups.

What is the Chicago White Sox ATS record vs the Baltimore Orioles?

The Chicago White Sox are 6-19-0 against the spread vs the Baltimore Orioles on DraftKings, with -54.96% ROI.

Do Chicago White Sox vs Baltimore Orioles games go over or under?

Chicago White Sox vs Baltimore Orioles games average 8.8 total points. The Over has hit 45.45% of the time.

More White Sox Matchups

See from Orioles perspective

Head-to-head betting record for Chicago White Sox vs Baltimore Orioles on LineTerminal. The White Sox are 10-21 straight up against the Orioles and 6-19-0 against the spread (24% cover rate, -54.96% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.