San Diego Padres Lead Pittsburgh Pirates 5-1 in Head-to-Head Matchups (2025)

MLB3-3-0 ATS (50%)Updated June 1, 2025

The Pittsburgh Pirates are 1-5 against the San Diego Padres in 2025 in head-to-head matchups, going 3-3-0 ATS (50% cover rate) with -15.67% ROI. Games average 6.7 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official MLB box scores.

See methodology.

Pirates vs Padres Betting Record — 2025

Against the Spread

3-3-0

Win %

50%

ROI

-15.67%

Units

-0.9

Moneyline

1-5-0

Win %

16.67%

ROI

-54.17%

Units

-3.3

Over Rate

2-4-0

Win %

33.33%

ROI

-37.35%

Units

-2.2

From the Other Side — Padres vs Pirates

Against the Spread

3-3-0

Win %

50%

ROI

+16.83%

Units

+1.0

Moneyline

5-1-0

Win %

83.33%

ROI

+46.49%

Units

+2.8

Over Rate

2-4-0

Win %

33.33%

ROI

-37.35%

Units

-2.2

Venue Splits

Pirates Home

1-2-0 ATS

33.33% • -48.15%

0-3-0 ML (0%)

Padres Home

1-2-0 ATS

33.33% • -21.67%

2-1-0 ML (66.67%)

Scoring Averages

Pirates

2.7

PPG

allowed

Total

6.7

Avg

games

Padres

PPG

2.7

allowed

Recent Matchups (2025)

Date	Matchup	Score	Spread	ATS	ML	O/U
06/012025-06-01	Pirates @ Padres	L 6-4	-1.5	✗	L	O
05/312025-05-31	Pirates @ Padres	W 0-5	-1.5	✓	W	U
05/302025-05-30	Pirates @ Padres	L 3-2	-1.5	✓	L	U
05/042025-05-04	Padres @ Pirates	L 0-4	-1.5	✗	L	U
05/032025-05-03	Padres @ Pirates	L 1-2	-1.5	✓	L	U
05/022025-05-02	Padres @ Pirates	L 4-9	-1.5	✗	L	O

Frequently Asked Questions

What is the Pittsburgh Pirates vs San Diego Padres 2025 record?

The Pittsburgh Pirates are 1-5 against the San Diego Padres in 2025 in head-to-head matchups.

What is the Pittsburgh Pirates ATS record vs the San Diego Padres?

The Pittsburgh Pirates are 3-3-0 against the spread vs the San Diego Padres in 2025 on DraftKings, with -15.67% ROI.

Do Pittsburgh Pirates vs San Diego Padres games go over or under?

Pittsburgh Pirates vs San Diego Padres games average 6.7 total points in 2025. The Over has hit 33.33% of the time.

More Pirates Matchups

See from Padres perspective

Head-to-head betting record for Pittsburgh Pirates vs San Diego Padres in the 2025 season on LineTerminal. The Pirates are 1-5 straight up against the Padres and 3-3-0 against the spread (50% cover rate, -15.67% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.