PatriotsAway29
BillsHome26SpreadCoverFav -7
MoneylineWin
TotalOver49.5
NFL · Head to head
Patriots vs Bills
All recorded seasonsLast meeting Oct 4, 2026
Betting comparison
All seasons
Patriots
14 bets8-6-0Wins · Losses · Pushes
- Win rate
- 57.14%
- ROI
- +9.71%
- Units
- +1.36u
Bills
14 bets6-8-0Wins · Losses · Pushes
- Win rate
- 42.86%
- ROI
- -18.1%
- Units
- -2.53u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsPatriots20.9
Bills27.4
Combined48.3
Recent meetings
Bet results from the Patriots perspective. Spread values show the favorite’s closing line.
PatriotsAway29BillsHome26BillsAway35PatriotsHome31SpreadMissFav -2.5
MoneylineLoss
TotalOver49.5
PatriotsAway23BillsHome20SpreadCoverFav -7.5
MoneylineWin
TotalUnder49.5
BillsAway16PatriotsHome23SpreadCoverFav -3
MoneylineWin
TotalOver36.5
PatriotsAway21BillsHome24SpreadCoverFav -14
MoneylineLoss
TotalUnder48
More Patriots matchups
About this matchup
What is the New England Patriots vs Buffalo Bills all-time record?
The New England Patriots are 5-9 against the Buffalo Bills in head-to-head matchups.
What is the New England Patriots ATS record vs the Buffalo Bills?
The New England Patriots are 8-6-0 against the spread vs the Buffalo Bills on DraftKings, with +9.71% ROI.
Do New England Patriots vs Buffalo Bills games go over or under?
New England Patriots vs Buffalo Bills games average 48.3 total points. The Over has hit 69.23% of the time.