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Home/MLB Schedule/Cardinals @ Pirates

St. Louis Cardinals vs Pittsburgh Pirates — Sep 22, 2026 Odds

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See methodology for grading rules and ROI calculation.

PNC Park59°F, wind 14 mph in from CF

STL

76-80

First pitch5:41 PMCDTUpcoming

PIT

79-77

Pre-game notes2 notes

Won 4 straightPirates on heater

Covered 5 straightPirates covering against the spread

Inside Edge Pick

Pirates -1.53 stars, 75% confident

Straight up: Cardinals 71%. Total 41.5.

Ballpark weatherPNC Park

In from left

10 mph ENE

60°Temp

10Wind

84%Humid

10%Precip

Starting pitchers

CardinalsConfirmed

Andre Pallante

3.70 ERA12-7151.0 IP104 K1.26 WHIP

Inside Edge

vs

PiratesConfirmed

Jared Jones

4.17 ERA4-690.2 IP109 K1.19 WHIP

Inside Edge

Batting order★ Inside Edge

CardinalsConfirmed

12B

JJ Wetherholt

.242 · 17 HR · .709 OPS

2DH

Iván Herrera

.247 · 18 HR · .746 OPS

31B

Alec Burleson

.282 · 23 HR · .813 OPS

4RF

Jordan Walker

.274 · 28 HR · .806 OPS

5C

Leo Bernal

.311 · 4 HR · .868 OPS

6LF

Bryan Torres

.239 · 4 HR · .659 OPS

73B

Thomas Saggese

.247 · 4 HR · .679 OPS

8CF

Nathan Church

.252 · 10 HR · .670 OPS

9SS

Masyn Winn

.235 · 5 HR · .629 OPS

PiratesConfirmed

1SS

Konnor Griffin

.267 · 5 HR · .711 OPS

22B

Brandon Lowe

.262 · 33 HR · .824 OPS

3LF

Bryan Reynolds

.262 · 17 HR · .788 OPS

4CF

Oneil Cruz

.280 · 20 HR · .857 OPS

5C

Rafael Flores Jr.

Rafael Flores Jr.

.286 · 10 HR · .910 OPS

6DH

Ryan O'Hearn

.264 · 18 HR · .774 OPS

7RF

Ronny Simon

.313 · 1 HR · .791 OPS

81B

Spencer Horwitz

Spencer Horwitz

.248 · 10 HR · .713 OPS

93B

Jacob Gonzalez

.223 · 6 HR · .631 OPS